ALTERATIONS TO DENDRITIC SPINE MORPHOLOGY, BUT NOT DENDRITE PATTERNING, OF CORTICAL PROJECTION NEURONS IN TC1 AND TS1RHR MOUSE MODELS OF DOWN SYNDROME.

Down Syndrome (DS) is a highly prevalent developmental disorder, affecting 1/700 births.Intellectual disability, which affects learning and memory, is present in all cases and is reflected by below average IQ.We sought to determine whether defective morphology and connectivity in neurons of the cerebral cortex may underlie the cognitive deficits th

AbstractWe employed a Bayesian analysis to compare offence-specific forgiveness in supportive versus ambivalent relationships.We also investigated offender accounts to assess their effect on forgiveness.Participants (283 total, 171 female) read a hypothetical scenario Denim wherein an offender from a supportive or ambivalent relationship transgress

Abstract Background Diabetes-associated cognitive impairment (DACI) poses a significant challenge to Feathers the self-management of diabetes, markedly elevating the risk of adverse complications.A burgeoning body of evidence implicates microglia as a central player in the pathogenesis of DACI.Methods We utilized proteomics to identify potential bi

Background:COVID-19 pandemic has afflicted cancer patients on various fronts including spiritual domain.The case series tries to highlight the spiritual beliefs and challenges faced by cancer patients and the transformation which has occurred during pandemic.Methods: Thirty consecutive cancer patients who attended outpatient clinic of cancer pain a

Labyrinth seals are a state-of-the-art GOGGLES sealing technology to prevent and control leakage flows at rotor–stator interfaces in turbomachinery.Higher pressure ratios and the economical use of cooling air require small clearances, which lead to potential rubbing events.The use of honeycomb liners allows for minimal leakage by tolerating r